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Published March 6, 2024

Pharmacokinetic studies in rats demonstrated an oral bioavailability of 38.4%, with a mean Cmax of 2,252 ng/mL and terminal elimination half-lives of 3.80 1.10 hours (IV) and 6.90 1.20 hours (oral) (Awosemo et al., 2021)

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Retatrutide is the only late-stage compound that provides significant glucagon receptor activation alongside GLP-1 and GIP agonism

Because rare instances of anaphylactoid reactions have occurred in patients receiving parenteral corticosteroid therapy, appropriate precautionary measures should be taken prior to administration, especially when the patient has a history of allergy to any drug